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Jayant Narang

Medical Director, Scientific and Medical Services, Medical Imaging

Bio

Having served as an independent reviewer and as a veteran board-certified radiologist, Jayant has a wealth of experience in using imaging to document the safety, efficacy, and effectiveness of new drugs in clinical trials. He has supported hundreds of hematology and oncology trials, multiple with immuno-oncology and CAR-T therapy, and frequently engages with KOLs to seek clarifications on response assessment criteria. He has presented abstracts with Dr. Bruce Cheson as co-author in the CLL space.

Role at Calyx

- Provide oversight and expertise to trials in Oncology and Hemat-oncology trials with special interest and extensive experience in Lymphoma, CLL, Multiple Myeloma, and Waldenstorm’s.

- Provide expertise on trial specific modifications to commonly used oncology assessment criteria.

Industry Experience

- Medical Director, Scientific and Medical Service, Calyx (Previously Parexel) (2019-present)

- Associate Medical Director, Scientific and Medical Service, PAREXEL (2017-2019)

- Staff Radiologist, Biotelemetry Research (formerly Virtualscopics Inc), Rochester, NY, (2011–2017)

Academic Experience

- MBBS (Medical School) from Pt.J.N.M.Medical College, Raipur, CG, India. Completed in 1998 and included one year of clinical rotating internship.

- MD, DNB (Radiology Board Certification) T.N.Medical College, Mumbai University, India. Completed in 2001.

- Fellowship in MRI, Dr.Balabhai Nanavati hospital Mumbai, India (Apr 2001 to Nov 2001).

- Research Fellowship in Neuroradiology (Henry Ford health System, Detroit, MI, USA). June 2009-October 2011.

Therapeutic Experience

Oncology Studies
- Ovarian Cancer (Phase II)
- Prostate Cancer (Phase II)
- Myelofibrosis (Phase I/II)
- Solid Tumors (Phase III)
- Melanoma (Phase II)
- Cervical Cancer (Phase II)
- Genito-urinary cancer (Phase II)

MSK Studies
- Rheumatoid Arthritis (Phase I/II/III)
- Cartilage Repair (Phase I/II/III)
- Muscular Dystrophies / Myositis /Muscle atrophy (Phase I/II/III)
- Metabolic Disorders (Phase I/II/III)
- Chest Imaging (Phase I/II)

CNS Studies
- CNS tumors (Phase I/II/III)
- Multiple Sclerosis (Phase I/II)

Publications

- Ali R, Khan M, Chang V, Narang J, Jain R, Marin H, Rock J, Kole M. MRI Pre- and Post-Embolization Enhancement Patterns Predict Surgical Outcomes in Intracranial Meningiomas. J Neuroimaging. 2016 Jan;26 (1):130-5. PMID:25996574.

- Jain, R., Narang, J., Griffith, B., Bagher-Ebadian, H., Scarpace, L., Littenberg, B., Mikkelsen, T., Schultz, L. Prognostic vascular imaging biomarkers in high-grade gliomas: Tumor permeability as an adjunct to blood volume estimates. Academic Radiol.2013 Apr;20(4):478-85. PMID:23498990.

- Patkar D, Narang J, Yanamandala R, Lawande M, Shah GV.Central nervous system tuberculosis: pathophysiology and imaging findings. Neuroimaging Clin N Am. 2012 Nov;22(4):677-705. PMID:23122262.

- Jain, R., Poisson, L., Narang, J., Scarpace L., Rosenblum, M., Rempel, S., Mikkelsen, T. Correlation of Perfusion Parameters with Genes Related to Angiogenesis Regulation in Glioblastoma: A Feasibility Study. AJNR Am J Neuroradiology 2012 Aug;33(7):1343-8.PMID:22422183.

- Jain, R., Poisson, L., Narang, J., Gutman, D., Flanders, A., Scarpace, L., Hwang, S., Holder, C., Wintermark, M., Colen, R., Kirby, J., Freymann, J., Daniel, B., Jaffe, C., Mikkelsen, T. Genomic mapping and survival prediction in glioblastoma: Role of tumor blood volume versus molecular sub-classification. Radiology.2013 Apr;267(1):212-20.PMID:23238158.

- Narang, J., Jain, R., Arbab, S.A., Mikkelsen, T., Scarpace L., Rosenblum, M., Hearshen, D., Babajani-Feremi, A. Differentiating Treatment Induced Necrosis from Recurrent/Progressive Brain Tumor using Non-model Based ‘Semi-quantitative’ Indices Derived from Dynamic Contrast Enhanced T1-weighted MR Perfusion. Neuro Oncology. 2011 Jul 29. PMID:21803763.

- Chang, V., Narang, J., Schultz, L., Issawi, A., Jain, R., Rock, J., Rosenblum, M. Computer aided volumetric analysis as a sensitive tool for the management of incidental meningiomas. Acta Neurochir (wein). 2012 Apr; 154(4):589-97. PMID: 22302235.

- Agarawal, A., Kumar, S., Narang, J., Schultz, L., Mikkelsen, T., Wang, S., Siddiqui, S., Poptani, H., Jain, R. Morphologic MRI features, diffusion tensor imaging and radiation dosimetric analysis to differentiate pseudo-progression from early tumor progression. J Neurooncol. 2013 May;112(3):413-20. PMID:23417357.

- Jain, R., Narang, J., Gutierrez, J., Schultz, L., Scarpace L., Rosenblum, M., Mikkelsen, T., Rock, J. Correlation of Immuno-histological and Perfusion Vascular Parameters with Contrast Enhancement using Image-guided Biopsy Specimens in Gliomas. Acad Radiol. 2011 Aug;18(8):955-62.

- Jain, R., Narang, J., Schultz, L., Scarpace L., Brown, S., Saksena, S., Rock, J.P., Rosenblum, M., Gutierrez, J., Mikkelsen, T. Permeability estimates in histopathology proven treatment induced necrosis using perfusion CT: Can these add to other perfusion parameters in differentiating from recurrent/progressive tumors? Am J Neuroradiology Apr 2011; 32: 658 - 663.

- Jain R, Narang J, Sundgren PM, Hearshen D, Saksena S, Rock JP, Gutierrez J, Mikkelsen T. Treatment induced necrosis versus recurrent/progressing brain tumor: going beyond the boundaries of conventional morphologic imaging. J Neurooncol. 2010 Feb 24. PMID: 20179990.

- Narang J, Jain R, Scarpace L et al. Tumor vascular leakiness and blood volume estimates in oligodendrogliomas using perfusion CT: an analysis of perfusion parameters helping further characterize genetic subtypes as well as differentiate from astroglial tumors. J Neuro-oncology 2011 Apr;102(2):287-93.

- Jain, R., Gutierrez, J., Narang, J., Scarpace L., Schultz, L., Lemke, N., Patel, S.C., Mikkelsen, T., Rock, J. In vivo correlation of tumor blood volume and permeability with histological and molecular angiogenic markers in gliomas. Am J Neuroradiology 2011; 32: 388 - 394.

- Saksena S, Jain R, Narang J, Scarpace L, Schultz LR, Lehman NL, Hearshen D, Patel SC, Mikkelsen T. Predicting survival in glioblastomas using DTI metrics. J Magnetic Resonance Imaging 2010;32:788-795.

- Lawande M, Patkar D, Pungavkar S, Narang J. A rare case of acute stroke-like onset of pontine glioma. Journal of Paediatrics & Child Health. 44(9):527-529, September 2008.

- Bagher-Ebadian, H., Jain, R., Nejad-Davarani, SP., Mikkelsen, T., Lu, M., Quan, J., Scarpace L., Arbab, S.A., Narang J, Soltanian-Zadeh, H., Paudyal, R., Ewing, J. R. Model selection for DCE-T1 studies in glioblastoma. Magnetic Resonance in Medicine 2012 Jul;68(1):241-51. PMID:22127934.

- Jain, R., Griffith, B. Narang, J., Mikkelsen, T., Bagher-Ebadian, H., Nejad-Davarani, SP.,Ewing, J. R., Arbab Ali, S. Blood-Brain Barrier Imaging in Brain Tumors: Concepts and Methods. Neurographics 2012 June; 2:48-59.

- Bagher-Ebadian, H., Jain, R., Khalighi, M. M., Nejad-Davarani, SP., Paudyal, R., Narang, J., Quan, J., Mikkelsen, T., Ewing, J. R. Magnetic Resonance Estimation of Longitudinal Relaxation Time (T1) in Spoiled Gradient Echo Using an Adaptive Neural Network. IEEE Transactions on Neural Networks IEEE-IJCNN 2011: 523 (73): 2557-2562. PMC 978-1-4244-9636-5.

- Naik RS, Narang J. Melorheostosis: Follow-up of a case Compounded with carcinoma prostate. Indian J Surg 2005;67:106-8.

- Naik RS, Narang J. Sigmoid Kidney Associated with Double Urethra. Indian J Surg Jan 2011 73(1):61–62. PMID 22211041.

- Lawande M, Tavri S, Patkar D, Pungavkar S, Narang J. Meniscal ossicle, a rare entity. Indian J Radiol Imaging 2008; 18:128-9.

- Bagher-Ebadian, H., Jain, R., Narang, J. Generalized linear model approach for diagnosis of coronary artery disease in nuclear medicine. J Nucl Med 2010; 51 (Supplement 2):82 (meeting abstract).

- Jain, R., Poisson, L., Narang, J., Scarpace, L., Gutman, D., Flanders, A., Brat, D., Jaffe, C., Mikkelsen, T. Survival Prediction Using Molecular Classification of Glioblastomas: Role of Tumor Blood Volume Estimation Using DSC T2* MR Perfusion. Neuro-Oncology 2011 13: 141-141. (meeting abstract).

Presentations

- Jayant Narang, Surabhi Bajpai, Rudresh Jarecha, Christiana Caplan Dana Macdonald, Gabriele Pradella, Manish Sharma, Bruce Cheson ``The Clinical Relevance of Residual, Persistent and Elongated Abnormal Sized Nodes by LDi+ in Patients with CLL, otherwise in CR. Blood (2020) 136 (Supplement 1): 34–35.

- Surabhi Bajpai, Jayant Narang, Shweta Narang ,Ravikanth Mankala, Rudresh Jarecha, Manish Sharma Mantle Cell Lymphoma: Incidence of Gastrointestinal Involvement and Correlation with Overall Response- Retrospective Review of Multiple Multicenter Trials Blood (2020) 136 (Supplement 1): 33–34.

- Jayant Narang, Surabhi Bajpai, Rudresh Jarecha, Manish Sharma, Oliver Bohnsack. Comparison of response using mRECIST versus RECIST 1.1 Criteria in advanced hepatocellular carcinoma – A retrospective analysis of multi-center clinical trials. ASCO 2020.

- Jayant Narang, Surabhi Bajpai, Rudresh Jarecha, Sayali Karve, Katarina Ludajic, Manish Sharma, Shweta Narang, Michael O'Connor. Comparison of CT and PET-Based Assessments per Lugano Criteria in FDG-Avid Lymphoma- a Retrospective Analysis of Independent Review Assessments. ASH 2019, published in Blood (2019) 134 (Supplement_1): 5277.

- Narang J, Bajpai S, Jarecha R, Ludajic K, Karve S, Kheterpal A, Mikhael J. Imaging in Multiple Myeloma: Independent review perspective for IMWG 2016 response assessment. XVIIth International Myeloma Symposium, Boston, September 2019.

- Manish Sharma. Oliver Bohnsack. Rudresh Jarecha, Jayant Narang, Anitha Singhareddy, Surabhi Bajpai. Identification of new lesions with disease progression in Ovarian cancer per RECIST 1.1; ePoster at ASCO 2020

- Jayant Narang, Surabhi Bajpai, Rudresh Jarecha, Sayali Karve, Katarina Ludajic, Manish Sharma, Oliver Bohnsack. Retrospective comparison of Cheson 2007 and Lugano classification criteria in independent review assessment of FDG-avid lymphomas. ASCO 2019

- Manish Sharma, Oliver Bohnsack, Daniel Clark, Michael O'Connor, Anitha Singareddy, Jayant Narang, Rudresh Jarecha. Impact and influence of PET on imaging related endpoints in patients with Lymphoma using IWG-NHL or Lugano classification. ASCO 2019.

- Chivate, R., Thakrar, P., Narang, J., Patkar, D., Kumar, S., Verma, M. PET CT in Autism a diagnostic tool. RSNA, Chicago, IL Nov-Dec 2014.

- Agarawal, A., Kumar, S., Narang, J., Schultz, L., Flanders, A., Mikkelsen, T., Jain, R. Differentiating pseudo-progression from true tumor progression in high grade gliomas using morphologic imaging features and radiation dosimetric analysis of morphologic features. 50th Annual meeting of ASNR, New York, NY, April 21-26, 2012.

Associations and Affiliations

- Radiological Society of North America (RSNA)
- American Society of Neuroradiology (ASNR)
- Indian Radiological and Imaging Association (IRIA)

Library

Utilizing Medical Imaging to Support Accelerated Approval

Earning the FDA’s prized Breakthrough Therapy designation is just the beginning of the race, one that likely requires the use of an imaging surrogate for preclinical evidence and accelerated approval.
Read more

Impact of PET on imaging related endpoints in lymphoma trials

We know that PET imaging is critical in determining response assessments in hematology trials but what do you do when PET scans are not always available? See what our experts have to say.
Read more

Behind the Breakthrough

Earning the FDA’s prized Breakthrough Therapy designation is just the beginning of the race, one that likely requires the use of an imaging surrogate for preclinical evidence and accelerated approval.
Read more

Reviewer Performance Monitoring in Blinded Independent Central Review Setting

This white paper reviews how the assessment of imaging data in support of surrogate endpoints by an independent entity reduces evaluation bias and improves assessment consistency in clinical trials.
Read more

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