Medical Imaging

Oncology

Oncology Expertise

Calyx scientific consultants have the industry’s most extensive experience in oncology clinical trial imaging. We’ve successfully managed the imaging components of over 1,500 clinical trials across 90 unique oncology indications. This includes more than 50 pivotal studies – where imaging data supported successful submissions to regulatory agencies – and over 75 trials of compounds that were designated breakthrough therapies.

 

Solid Tumor

During the course of anti-tumor treatment development, imaging modalities, criteria, and regulators’ expectations change frequently. Without the direction of imaging scientists who work day in and day out in clinical trial imaging, it would be difficult, if not impossible to keep track of and react to changes during these critical and oftentimes, lengthy trials.

Calyx’s scientific and medical experts have successfully managed the important imaging components of over 1,300 solid tumor trials – in all phases of clinical development across multiple indications such as cancer of the prostate, breast, bladder, and many more. You can trust Calyx to guide you through the highly nuanced and technically challenging world of clinical trial imaging to ensure your solid tumor development program succeeds. Or if it’s going to fail, to fail fast.

Calyx Medical Imaging: Oncology Trial Experience >

Hematology

Calyx’s expert scientific and medical team is experienced in the successful implementation and operationalization of hematology trials, providing solutions to manage complex clinical data and advanced imaging. Our experience includes 300+ hematology trials, including support of 40+ approvals in Lymphoma, CLL, Waldenstorms and Multiple Myeloma.

Calyx has close collaborations with key opinion leaders including Dr. Bruce Cheson, Dr. Joseph Mikhael and Dr. Shaji Kumar, which enables us to address criteria gaps and we work closely with a large pool of board-certified reviewers from renowned institutes with extensive experience in various hematology criteria including Lugano, iwCLL, IMWG, LYRIC, RECIL etc.

You can trust the Calyx Medical Imaging team to provide reliable consultation on hematology trial design, template charters, and applications based on our lessons learned from previous studies incorporating reviewer, KOL, and regulatory feedback.

Neuro-oncology

Calyx provides a wide range of proven imaging services for Neuro-oncology clinical trials. Our network of scientific advisors and in-house expertise allows for full spectrum service offerings to help take your product from discovery to market.

Calyx’s experience in Neuro-oncology imaging includes:

— Primary or metastatic tumor detection/propagation on contrast-enhanced CT & MRI utilizing appropriate criteria and analysis approaches
— Superimposition of sequences to segment out tumor and edema volumes and follow over time
— Advanced MRI analysis per study needs

Innovating the Science

Calyx employs some of the industry’s key thought leaders, including Dr. Oliver Bohnsack who wrote the book on medical imaging in oncology trials – literally. Dr. Bohnsack leverages his knowledge from having co-authored the immune-related response criteria (irRC, 2009), served as first author of irRECIST (2014), and co-authored Comparison of Assessments using RECIST and irRECIST by Manitz J. et al. (2020) as he designs and implements optimal imaging strategies for Calyx’s customers developing new oncology treatments.

MEET THE EXPERTS

Global Support

Calyx’s Medical Imaging team leverages our established operational footprint to implement an imaging strategy that acquires complex yet optimized CNS images from investigative sites around the world.

With local support in India, China, North America, and Europe, you can have confidence that the imaging components of your CNS trial will run smoothly and deliver high quality data you can rely on. Every time.

Discover Our Therapeutic Expertise

Calyx’s expertise spans across all phases of clinical development and therapeutic areas. In addition to Oncology, we have significant experience and proven capabilities in providing medical imaging services to support the clinical development of new treatments in oncology, musculoskeletal, and many other therapeutic areas.

Library

Improving how we Evaluate Treatment Response in Oncology Research

Join the discussion on irRecist with Calyx’s Head of Oncology, Dr. Oliver Bohnsack and discover what's next in oncology research.
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Identifying Reader Fatigue in Oncology Trial Imaging

Fatigue is an insidious, pervasive and often overlooked issue in oncology trial imaging. Identifying reader fatigue and understanding its impact on image interpretation can help shape the design, selection and management of clinical trials.
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Advanced Reviewer Monitoring Improves Clinical Trial Imaging Quality

Join us to see how we can simplify in an easy-to-understand manner, the highly complex statistically driven metrics that have been applied at Calyx to support a robust data-driven quality monitoring process.
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Calyx Supports Breakthrough Therapy Approvals for Oncology Treatments

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