Preclinical Radioligand Therapy to Advance Radiopharmaceuticals

Q: What RLT services does Perceptive offer in the preclinical setting?

Perceptive delivers fully integrated preclinical RLT services encompassing radiolabeling, biodistribution, dosimetry, efficacy, and image analysis all supported by a deep bench-to-bedside workflow designed to generate translatable, IND-enabling data to accelerate radiopharmaceutical development.

Q: What scale and infrastructure support Perceptive’s RLT capabilities?

We have supported 900+ preclinical RLT studies and 50+ dosimetry studies across species, all executed through our global network of six preclinical labs with integrated radiochemistry centers.

Q: Which preclinical imaging modalities and isotopes are employed in RLT studies?

Our RLT program includes a full imaging suite (PET, SPECT, MRI, CT, IVIS, and cryofluorescence tomography [CFT]) and extensive experience with both alpha emitters (e.g., Ac-225, Pb-212, At-211) and beta emitters (e.g., Lu-177, Cu-67, Tb-161, I-131, Y-90).

Q: How does Perceptive support preclinical dosimetry and dose modeling for RLT programs?

We apply regulatory grade dosimetry, performing both direct and surrogate isotope imaging across multiple species (from rodents to non-human primates). These studies support dose estimation, organ toxicity prediction, and evaluation of radionuclide daughter translocation.

Q: What efficacy endpoints are included in Perceptive’s preclinical RLT studies?

Perceptive’s RLT studies integrate longitudinal efficacy monitoring assessing tumor regression, survival outcomes, and hematology/clinical chemistry biomarkers while comparing candidates to standards of care. Results are correlated with dosimetry and biomarker data to inform translational decisions.

From radiolabeling and biodistribution to dosimetry and efficacy in diverse animal models, Perceptive Discovery delivers integrated, translatable data to accelerate your radiopharmaceutical pipeline from concept to clinic.

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Preclinical Radioligand Therapy

The Leading Preclinical Imaging Partner for Radiopharmaceutical Development

Perceptive Discovery offers comprehensive preclinical RLT services to support the discovery and development of radiopharmaceutical therapies. We work with biotech and pharmaceutical teams to design and execute custom studies that generate the translational data needed for IND submission and clinical advancement.

Our team of radiochemists, pharmacologists, cancer biologists, and imaging scientists bring deep expertise across a broad spectrum of isotopes, modalities, and therapeutic platforms. Whether developing a novel targeted radiotherapeutic or a companion diagnostic, we streamline radiolabeling, dosimetry, efficacy, and image analysis—all under one roof.

With over 900+ preclinical RLT studies supported, and 50+ IND-enabling dosimetry studies, we are a proven partner in bringing first-in-class radiopharmaceuticals to the clinic.

Global infrastructure: 6 preclinical labs with integrated radiochemistry centers
Full suite of multi-modality imaging: PET, SPECT, MRI, CT, IVIS, CFT
Experience across tumor types and administration routes
Extensive Alpha/Beta Emitter experience:
- Alpha Emitters: ²²⁵Ac, ²¹²Pb, ²¹¹At
- Beta Emitters: ¹⁷⁷Lu, ⁶⁷Cu, ¹⁶¹Tb, ¹³¹I, ⁹⁰Y

End-to-End Support for Radiopharmaceutical Development

With over 900+ preclinical RLT studies supported, and 50+ IND-enabling dosimetry studies, we are a proven partner in bringing first-in-class radiopharmaceuticals to the clinic.

Radiolabeling & Chemistry Services

Custom radiolabeling of small molecules, peptides, antibodies, nucleic acids, cells, and nanoparticles
- Isotope platforms for PET, SPECT, and therapy: ¹⁸F, ^89Zr, ^64/67Cu, ^68Ga, ¹⁷⁷Lu, ²²⁵Ac, ^212/203Pb, ^131/125I, ²¹¹At
- Chelation chemistry and isotope pairing for theranostic applications
- In-house purification, QC, and stability testing
Biodistribution & PK/PD Imaging
Quantification of tumor and tissue uptake using matched diagnostic/therapeutic pairs (e.g., ²⁰³Pb/²¹²Pb, ^89Zr/²²⁵Ac, ¹¹¹In/²²⁵Ac, ¹⁸F/²¹¹At)
Evaluate systemic distribution, target specificity, and clearance
Longitudinal studies across small and large animal models utilizing multiple routes of administration

Dosimetry & IND-Enabling Studies

Regulatory-grade dosimetry using direct and surrogate isotope imaging
Species: mouse, rat, NHP (cynomolgus monkey)
Dose estimation and organ toxicity prediction
Evaluation of radionuclide daughter translocation and clearance

Efficacy in In Vivo Tumor Models

Monitor tumor regression and survival outcomes
Assess in-life and endpoint toxicity with hematology (CBC) and clinical chemistry biomarkers
Compare candidate efficacy to standard of care
Correlate therapeutic response with dosimetry and biomarker expression

Preclinical imaging scan of small animals showing skeletal structure with highlighted regions of radiotracer uptake in bright red, yellow, and purple tones, indicating areas of biological activity.

Anti tumour-muc-1 antibody labelled with DOTA and imaged in mice using 111In.
Kelly V.J. et al Theranostics 2020, Vol. 10, Issue 15

Two-panel scientific graph showing tumor growth and survival in mice after treatment. Panel A (left): Line graph of change in tumor volume (%) versus days post injection. Mice treated with ^225Ac–DOTA–hTAB004 (red lines) show minimal tumor growth, with tumor volume remaining near baseline. Mice treated with DOTA–hTAB004 (blue lines) show sharp increases in tumor volume over time, reaching above 1500% by around day 20–35. Panel B (right): Kaplan–Meier survival curve of survival duration (days) versus survival percentage. All mice treated with ^225Ac–DOTA–hTAB004 (red line) survive through the study (100% survival up to ~50 days). Mice treated with DOTA–hTAB004 (blue line) show declining survival starting around day 17, with 0% survival by day 35. Legend indicates red for ^225Ac–DOTA–hTAB004 and blue for DOTA–hTAB004.

Mice treated with 225Ac-labelled anti tumour-muc-1 antibody A) Tumor volume in animals administered with 225Ac-DOTA-hTAB004 (red) compared to control animals administered DOTA-hTAB004 (blue) as monitored for the duration of the study. Intra-group comparisons of percentage change in tumor volume at each study day; * P<0.05, # P<0.01, ^ P<0.001. (B) Kaplan-Meier survival curves showing 100% survival in treatment group until the end of the study (D=48; red) and 0% survival in control group (blue).
Kelly V.J. et al Theranostics 2020, Vol. 10, Issue 15

Frequently Asked Questions

1. What RLT services does Perceptive offer in the preclinical setting?

Perceptive delivers fully integrated preclinical RLT services encompassing radiolabeling, biodistribution, dosimetry, efficacy, and image analysis all supported by a deep bench-to-bedside workflow designed to generate translatable, IND-enabling data to accelerate radiopharmaceutical development.

2. What scale and infrastructure support Perceptive’s RLT capabilities?

We have supported 900+ preclinical RLT studies and 50+ dosimetry studies across species, all executed through our global network of six preclinical labs with integrated radiochemistry centers.

3. Which preclinical imaging modalities and isotopes are employed in RLT studies?

Our RLT program includes a full imaging suite (PET, SPECT, MRI, CT, IVIS, and cryofluorescence tomography [CFT]) and extensive experience with both alpha emitters (e.g., Ac-225, Pb-212, At-211) and beta emitters (e.g., Lu-177, Cu-67, Tb-161, I-131, Y-90).

4. How does Perceptive support preclinical dosimetry and dose modeling for RLT programs?

We apply regulatory grade dosimetry, performing both direct and surrogate isotope imaging across multiple species (from rodents to non-human primates). These studies support dose estimation, organ toxicity prediction, and evaluation of radionuclide daughter translocation.

5. What efficacy endpoints are included in Perceptive’s preclinical RLT studies?

Perceptive’s RLT studies integrate longitudinal efficacy monitoring assessing tumor regression, survival outcomes, and hematology/clinical chemistry biomarkers while comparing candidates to standards of care. Results are correlated with dosimetry and biomarker data to inform translational decisions.

Scientist wearing blue gloves pouring liquid into test tubes, overlaid with geometric shapes and pink microscopic texture pattern.

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